CALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics Rho-kinase inhibition attenuates airway responsiveness, inflammation, matrix remodeling, and oxidative stress activation induced by chronic inflammation
نویسندگان
چکیده
Samantha Souza Possa, Homar Toledo Charafeddine, Renato Fraga Righetti, Patricia Angeli da Silva, Rafael Almeida-Reis, Beatriz Mangueira Saraiva-Romanholo, Adenir Perini, Carla Máximo Prado, Edna Aparecida Leick-Maldonado, Milton A. Martins, and Iolanda de Fátima Lopes Calvo Tibério Department of Medicine, School of Medicine, University of São Paulo, and Department of Biological Science, Federal University of São Paulo, Diadema, São Paulo, Brazil
منابع مشابه
Y-27632 is associated with corticosteroid-potentiated control of pulmonary remodeling and inflammation in guinea pigs with chronic allergic inflammation
BACKGROUND Previously, we showed that treatment with the Rho-kinase inhibitor Y-27632 was able to control airway responsiveness, inflammation, remodeling, and oxidative stress in an animal model of asthma, suggesting that this drug is beneficial in asthma. However, studies evaluating the effects of these inhibitors in conjunction with corticosteroids on chronic pulmonary inflammation have not b...
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Proteinase inhibitors have been associated with anti-inflammatory and antioxidant activities and may represent a potential therapeutic treatment for emphysema. Our aim was to evaluate the effects of a plant Kunitz proteinase inhibitor, Enterolobium contortisiliquum trypsin inhibitor (EcTI), on several aspects of experimental elastase-induced pulmonary inflammation in mice. C57/Bl6 mice were int...
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تاریخ انتشار 2012